The research agenda of Sherman College includes developing vertebral subluxation (VS) measures and determining the effect of VS on quality of life. The VS measures and experimental design of Sherman College suggest using common measures that would allow for comparison of techniques for effectiveness in location and analysis of vertebral subluxation. (1) The reasons stated for the use of common, multiple measures are as follows. There is no irrefutable standard and the measures used commonly are hypothetical and subjective. There is a covariance of neurologic and articular function that leads to confusion about the reliability of specific measures. Until research into the reliability of a specific technique to measure the VS becomes more prevalent, it would be logical to use multiple indicators for analysis of the presence and location of a subluxation. (2) These indicators, to be useful, would have minimal overlap in the structure or functional attributes being investigated. For example, the palpation of the bony processes of the spine and the use of instrumentation are clearly different in technique and in the effects of subluxation being measured. (3) The motion of a joint and the x-ray analysis of the segment being palpated provide different measures that could both, arguably, be strong measures of the subluxation, or aspects of the subluxation. The combination of analysis is superior at the determination of the presence and location of subluxation when compared to any single method of analysis.